Virology

A significant part of my research has been associated with virology. Viruses offer, in my view, one of the most interesting windows to learn about evolution. They have small genomes with a potential to change very rapidly. Thus they give an excellent opportunity to see how evolution operates at the molecular level.

I have done work on more than a dozen different viruses. One line of research has been to change viral genomes (directed mutagenesis) in order to gain insight into the function of different parts of the genome. Another long standing interest has been to follow the evolution of viruses by seeing how genomes change over time, for example by following an outbreak of a viral disease (molecular epidemiology). Finally, I have worked on the development of proteinase inhibitors as medicine against HIV.

See no 29, 33-35, 36-41, 43-52, 55-58, 61-71, 73, 75-77, 80-84, 86, 88-91, 96-97, 99-103 on Reference List.