Johanne Egge Rinholm

Postdoc in The Brain and Muscle Energy Group [link]
Group leader: Linda H. Bergersen

Department of Anatomy and
Centre of Molecular Biology and Neuroscience
University of Oslo
PO Box 1105 Blindern
Oslo, Norway
Tel: +47-22 85 14 83
Email: j.e.rinholm@medisin.uio.no

Research interests:
I study the interactions between brain energy metabolism and neuronal signaling. This includes determining how different brain cells may use alternative energy fuels to glucose, such as lactate and ketone bodies, and how glutamatergic signaling affects mitochondrial motility. I use immunohistochemical methods (electron microscopy, confocal microscopy and western blotting), organotypic slice cultures and time-lapse fluorescence imaging in conjunction with patch-clamp recording.

Publications:
Rinholm JE, Hamilton NB, Kessaris N, Richardson WD, Bergersen LH, Attwell D. Regulation of oligodendrocyte development and myelination by glucose and lactate.  Journal of Neuroscience. In Press.

MacAskill AF, Rinholm JE*, Twelvetrees AE*, Arancibia-Carcamo IL, Muir J, Fransson Å, Aspenström P, Attwell D, Kittler JT (2009) Miro1 is a calcium sensor for glutamate receptor dependent localization of mitochondria at synapses. Neuron 26;61(4):541-55. (*joint second authors). [Pubmed]

Jensen V*, Rinholm JE*, Johansen TJ, Medin T, Storm-Mathisen J, Sagvolden T, Hvalby Ø, Bergersen LH (2009) N-methyl-d-aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention-deficit/hyperactivity disorder. Neuroscience 158(1): 353-64. (*joint first authors). [Pubmed]

Rinholm JE, Slettaløkken G, Marcaggi P, Skare Ø, Storm-Mathisen J, Bergersen LH (2007) Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents. Neuroscience 145(2): 579-91. [Pubmed]

Bergersen LH, Morland C, Rinholm JE, Ormel L, Wold JFH, Stranna A, Ottersen OP, Volterra A, Gundersen V (2009) Immunogold detection of L-glutamate and D-serine in small synaptic like microvesicles in adult hippocampal astrocytes. Submitted.