simulation of release, diffusion and uptake of neurotransmitter.
Glutamate molecules from one synaptic vesicle are released into the synaptic cleft, diffuse
out of the cleft
and into the surrounding microenvironment. The high amount oftransporters of the postsynaptic side of the synapse leads to an asymmetric glutamate profile. Thus, escaping glutamate is more
likely to reach
receptors surrounding the presynaptic side of the synapse than those surrounding the postsynaptic side (Lehre and Rusakov, 2002; Rusakov and Lehre, 2002).
are more glial cell membranes surrounding the postsynaptic than the presynaptic part of the synapse (Lehre and Rusakov, 2002). These membranes contain a high density of glutamate transporters (Lehre
1998). In addition, the postsynaptic membranes contain transporters (Dehnes et al., 1998). Thus, most of the identified transporter molecules are
localized near the
postsynaptic part of the synapse.