Mitogroup

At the Institute of Clinical Biochemistry, University of Oslo

We are a group of people who share common interest in mitochondrial function and mitochondrial DNA maintenance and implication in pathogenesity and aging, especially aging-related syndromes such as neurodegeneration and cancer.

We are an associated group of the Laboratory for molecular biology at the Centre of Molecular Biology and Neuroscience, and located at Rikshospitalet in Gaustad.

 

 

The People:

Pia Madeleine Øistad PhD student, Ruth Halsne PhD student, Pia Nenseth Auk Technician, Janne Maren Strand Technician,  Lars Eide Group leader, Ass.Prof.

 

Mitochondria play a central role in cellular processes as they actively participate in energy production, calcium buffering and apoptosis control. Erosion of mitochondrial function is

thought to underlie the progressive cell death observed in different neurodegenerative diseases and in aging in general. Damages to mitochondrial DNA are fixed by

specialized DNA repair systems, but extensive damage exceed repair capacity and can result in mitochondrial dysfunction which predisposes to cell death.

In our projects, we investigate how mitochondrial DNA status determines cellular tolerance to stress conditions.

Understanding molecular mechanisms that contribute to bioenergetic failure is essential for protection as well as treatment of disease.

 

We are collaborating with research groups within neuroscience as well as other areas focusing on oxidative stress, mitochondrial DNA damage and mitochondrial function.

In collaboration with Berit Woldseth at the Department of Medical Biochemistry, Rikshospitalet, we are establishing diagnostics for detection of mitochondrial diseases

Contact information:

23070947, 23070923, Institute of Clinical biochemistry is located on the 3rd floor, above the personal cafeteria at Rikshospitalet (see picture).

 

Projects:

-Characterization of mitochondrial DNA repair mechanisms and importance for cellular homeostasis (PMØ, JS, LE)
-Characterization of mitochondrial DNA mutation accumulation as function of age and repair deficiency (RH, LE)
-Characterization of mitochondrial role of neuronal calcium homeostasis (LE)
-Evaluating bioenergetic cost of mitochondrial DNA damage (PNA, PMØ, RH, JS, LE)

 

Future:

 

We have available projects for candidates for Master Study or “Forskerlinjeprosjekt”.

Contact us, or visit us at the institute of clinical biochemistry.

There is a vacant position as technician, associated to the group, see: http://www.admin.uio.no/opa/ledige-stillinger/2007/adm/avdingKliniskbiokjemi-07-2874.html

 

 

Moving mt in a striatal neuron

National Collaborators:

Professorstipendiat Kristin Austlid Tasken, Oslo Urologiske Universitetsklinikk, Aker universtitetssykehus

 

Professor Terje Rootwelt, terje.rootwelt@rikshospitalet.no, Barneklinikken, Rikshospitalet-Radiumhospitalet HF

 

 

 

International Collaborators:

Professor Cynthia T.McMurray, Mayo Clinic, Rochester, 55905 MN

Professor Jan H.Hoeijmakers, University of Rotterdam, Netherlands

Professor Huangen Ding, Luisiana State University, LA

Professor John Essigmann, MIT, MA

Professor VA Bohr, NIH, MD

Professor Bruce Demple, HSPH, MA

As part of the former Seeberg-group, we collaborate with this group lead by Magnar Bjørås, in addition to the group lead by Arne Klungland at the same institute.

 

Sponsors:

Norsk Forskningsråd (FUGE)

Universitetet i Oslo (EMBIO)

 

Productions (04->)

Ringvoll, J., Uldal, L., Aslaksen M.R., Reite,K., Baynton,K., Klungland, A. and Eide, L.“Mutations in the RAD27 and SGS1 genes differently affect chronological and replicative lifespan of respiring and fermenting yeast cells”

submitted.

 

Halsne, R., Oistad,P.M., Gran,C., Saether,B.E., Forstroem,R.F., vander Pluijm,I., Klungland,A. and Eide, L.Repair of oxidative damage in mitochondrial DNA sensitizes csb-/- cells to oxidative stress” submitted

 

Eide L, McMurray CT (2005) Culture of adult mouse neurons Biotechniques 38, 99-104.

Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Van Houten B, Zeitlin S, McNiven M, Aeberold R, Hayden M, Parii JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT (2004) Mutant Huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro, Mol Cell Biol 18, 8195-209.

updated 26/2-2007