At the Institute of Clinical Biochemistry, University of
We are a group of people who share common interest in mitochondrial function and mitochondrial DNA maintenance and implication in pathogenesity and aging, especially aging-related syndromes such as neurodegeneration and cancer.
We are an associated group of the Laboratory for molecular biology at the Centre of Molecular Biology and Neuroscience, and located at Rikshospitalet in Gaustad.
Pia Madeleine Øistad PhD student, Ruth Halsne PhD student, Pia Nenseth Auk Technician, Janne Maren Strand Technician, Lars Eide Group leader, Ass.Prof.
Mitochondria play a central role in cellular processes as they actively participate in energy production, calcium buffering and apoptosis control. Erosion of mitochondrial function is
thought to underlie the progressive cell death observed in different neurodegenerative diseases and in aging in general. Damages to mitochondrial DNA are fixed by
specialized DNA repair systems, but extensive damage exceed repair capacity and can result in mitochondrial dysfunction which predisposes to cell death.
In our projects, we investigate how mitochondrial DNA status determines cellular tolerance to stress conditions.
Understanding molecular mechanisms that contribute to bioenergetic failure is essential for protection as well as treatment of disease.
We are collaborating with research groups within neuroscience as well as other areas focusing on oxidative stress, mitochondrial DNA damage and mitochondrial function.
In collaboration with Berit Woldseth at the Department of Medical Biochemistry, Rikshospitalet, we are establishing diagnostics for detection of mitochondrial diseases
biochemistry is located on the 3rd floor, above the personal cafeteria at Rikshospitalet (see picture). Instituteof Clinical
-Characterization of mitochondrial DNA repair mechanisms and importance for cellular homeostasis (PMØ, JS, LE)
-Characterization of mitochondrial DNA mutation accumulation as function of age and repair deficiency (RH, LE)
-Characterization of mitochondrial role of neuronal calcium homeostasis (LE)
-Evaluating bioenergetic cost of mitochondrial DNA damage (PNA, PMØ, RH, JS, LE)
We have available projects for candidates for Master Study or “Forskerlinjeprosjekt”.
Contact us, or visit us at the institute of clinical biochemistry.
There is a vacant position as technician, associated to the group, see: http://www.admin.uio.no/opa/ledige-stillinger/2007/adm/avdingKliniskbiokjemi-07-2874.html
Moving mt in a striatal neuron
Professorstipendiat Kristin Austlid Tasken, Oslo Urologiske Universitetsklinikk, Aker universtitetssykehus
Professor Terje Rootwelt, firstname.lastname@example.org, Barneklinikken, Rikshospitalet-Radiumhospitalet HF
Professor Cynthia T.McMurray, Mayo Clinic,
, 55905 MN Rochester
Professor Jan H.Hoeijmakers,
University of Rotterdam, Netherlands
Professor Huangen Ding,
Luisiana State University, LA
Professor John Essigmann,
Professor VA Bohr, NIH, MD
Professor Bruce Demple,
Norsk Forskningsråd (FUGE)
Universitetet i Oslo (EMBIO)
Ringvoll, J., Uldal, L., Aslaksen M.R., Reite,K., Baynton,K., Klungland, A. and Eide, L.“Mutations in the RAD27 and SGS1 genes differently affect chronological and replicative lifespan of respiring and fermenting yeast cells”
Halsne, R., Oistad,P.M., Gran,C., Saether,B.E., Forstroem,R.F., vander Pluijm,
I., Klungland,A. and Eide, L.“Repair of oxidative damage in mitochondrial DNA sensitizes csb-/- cells to oxidative stress” submitted
McMurray CT(2005) Culture of adult mouse neurons Biotechniques 38, 99-104.
Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Van Houten B, Zeitlin S, McNiven M, Aeberold R, Hayden M, Parii JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT (2004) Mutant Huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro, Mol Cell Biol 18, 8195-209.