Harald Stenmark
2003
Petiot A, Fauré J, Stenmark H and Gruenberg J (2003). PI3P signaling
regulates receptor sorting but not transport in the endosomal pathway.
J.Cell Biol. , in press
Bache KG, Brech A, Mehlum A and Stenmark H (2003). Hrs regulates multivesicular
body formation via ESCRT recruitment to endosomes. J.Cell Biol.
, in press
Bache KG, Raiborg C, Mehlum A and Stenmark H (2003) STAM and Hrs are subunits
of a multivalent ubiquitin-binding complex on early endosomes. J. Biol.
Chem. 278: 12513-12521
Raiborg C, Rusten TE and Stenmark H (2003). Protein sorting into multivesicular
endosomes. Curr.Opin.Cell Biol.: In press.
Birkeland HCG and Stenmark H (2003). Protein targeting to endosomes and phagosomes
via FYVE and PX domains. Curr.Top.Microbiol.Immunol.: In press.
Stenmark H (2003) The FYVE finger – a phosphoinositide binding domain. In
“Zinc finger proteins” (Iuchi S and Kuldell N, eds.), Landes
Biosciences, Boston. In press.
2002
Bache KG, Raiborg C, Mehlum A, Madshus IH and Stenmark H (2002) Phosphorylation
of Hrs downstreatm of the epidermal growth factor receptor. Eur.J.Biochem.:
269: 3881-3887
Panapoulou E, Gillooly DJ, Wrana J, Zerial M, Stenmark H, Murphy C and
Fotsis T (2002). Early endosomal regulation of Smad-dependent signaling in
endothelial cells. J.Biol.Chem. 277: 18046-18052
(454 Kb)
Murray JT, Panaretou C, Stenmark H, Miaczynska M and Backer JM (2002) Role
of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic
3: 237-248
(477 Kb)
Stenmark H, Aasland R and Driscoll P (2002). The phosphatidylinositol 3-phosphate-binding
FYVE finger. FEBS Lett. 513: 77-84
(755 Kb)
Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H and
Olkkonen VM (2002). The small GTPase Rab22 interacts with EEA1 and controls
endosomal membrane trafficking. J.Cell Sci. 115: 899-911
(925 Kb)
Raiborg C, Bache KG, Gillooly DJ, Madshus IH, Stang E and Stenmark H (2002) Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nature Cell Biol. 4: 394-398
Raiborg C and Stenmark H (2002) Hrs and endocytic sorting of ubiquitinated proteins.. Cell Struct.Funct..: 27: 403-408
2001
Gillooly D, Simonsen A and Stenmark H (2001). Phosphoinositides and phagocytosis.
J. Cell Biol. 155: 15-17
(163 Kb)
Pattni K, Jepson M, Stenmark H and Banting G (2001). A PI(3)P specific
probe cycles on and off host cell membranes during Salmonella invasion
of mammalian cells. Curr.Biol. 11: 1636-1642
Raiborg C, Bache KG, Mehlum A, Stang E and Stenmark H (2001) Hrs recruits
clathrin to early endosomes. EMBO J. 20: 5008-5021
(722 Kb)
Simonsen A and Stenmark H (2001) PX domains: attracted by phosphoinositides. Nature Cell Biol. 3: E179-E182
Gillooly DJ and Stenmark H (2001) A lipid oils the endocytosis machine. Science 291: 993-994
Kim DH, Eu YJ, Yoo CM, Kim YW, Pih KT, Jin JB, Kim SJ, Stenmark H and Hwang I (2001) Trafficking of phosphatidylinositol 3-phosphate from the trans-Golgi network to the lumen of the central vacuole in plant cells. Plant Cell 13: 287-301
Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D’Arrigo
A, Stang E and Stenmark H (2001) FYVE and coiled-coil domains determine
the specific localisation of Hrs to early endosomes. J.Cell Sci.
114: 2255-2263
(850 Kb)
Stenmark H (2001) Trafficking of lipids. Semin.Cell Dev.Biol.
12: 135-137
Stenmark H and Gillooly DJ (2001) Intracellular trafficking and turnover
of phosphatidylinositol 3-phosphate. Semin.Cell Dev.Biol. 12:
193-199
Raiborg C, Bache KG, Mehlum A and Stenmark H (2001) The function of Hrs
in endocytic signalling and trafficking. Biochem.Soc.Trans.
29: 472-475
Simonsen A, Wurmser A, Emr SD and Stenmark H (2001) The role of phosphoinositides
in intracellular membrane trafficking. Curr.Opin. Cell Biol.
13: 485-492
Stenmark H and Olkkonen VM (2001) The Rab GTPase family. Genome Biol. 2: 3007.1-3007.7
Gillooly DJ, Simonsen A and Stenmark H (2001) Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins. Biochem.J. 355: 249-258
Stenmark, H. and Zerial, M. (2001). Molecular mechanisms of membrane fusion
in the endocytic pathway. In Endocytosis (M. Marsh, ed.), Frontiers
in Molecular Biology series, Oxford University Press, pp. 94-110
2000
Gaullier J-M, Rønning E, Gillooly DJ and Stenmark H (2000) Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues. J.Biol.Chem. 275: 14595-24600
Gillooly DJ, Morrow, IC, Lindsay M, Gould R, Bryant, NJ, Gaullier J-M,
Parton RG and Stenmark H (2000) Localization of phosphatidylinositol 3-phosphate
in yeast and mammalian cells. EMBO J. 19: 4577-4588
(892 Kb)
Urbé, S., Mills, I.G., Stenmark, H., Kitamura, N., and Clague, M.J. (2000). Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. Mol.Cell.Biol. 20: 7685-7692
Duclos, S., Diez, R., Garin, J., Descoteaux, A., Stenmark, H. and Desjardins, M. (2000) Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages. J. Cell Sci. 113: 3531-3541
Stenmark H (2000) Cycling lipids. Curr. Biol. 10: R57-R59
Stenmark H (2000) Phosphatidylinositol 3-kinase and membrane trafficking.
In Biology of phosphoinositides (S. Cockcroft, ed.), Frontiers
in Molecular Biology series, Oxford University Press, pp 239-267.
1999
Callaghan J, Simonsen A, Gaullier J-M, Toh B-H and Stenmark H (1999) The endosome fusion regulator EEA1 is a dimer. Biochem.J. 338: 539-543
Simonsen A, Gaullier J-M, D’Arrigo A and Stenmark H (1999). The Rab5 effector EEA1 interacts directly with syntaxin-6. J.Biol.Chem. 274: 28857-28860
Callaghan J, Nixon S, Bucci C, Toh B-H and Stenmark H (1999). Direct interaction of EEA1 with Rab5b. Eur.J.Biochem. 265: 361-366
Gaullier J-M, Simonsen A, D’Arrigo A, Bremnes B and Stenmark H (1999) FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate. Chem. Phys. Lipids 98: 87-94
Corvera S, D’Arrigo A and Stenmark H (1999). Phosphoinositides in membrane traffic. Curr. Opin. Cell Biol. 11: 460-465
Gaullier J-M, Gillooly D, Simonsen A and Stenmark H (1999). Regulation of endocytic membrane traffic by phosphatidylinositol 3-phosphate. Biochem. Soc. Trans. 27: 666-670
Stenmark H and Aasland R (1999). FYVE finger proteins - effectors of an
inositol lipid. J. Cell Sci. 112: 4175-4183
1998
Simonsen A, Bremnes B, Rønning E, Aasland R and Stenmark H (1998) Syntaxin-16, a putative Golgi t-SNARE. Eur. J. Cell Biol. 75: 223-231
Zacchi P, Stenmark H, Parton RG, Orioli D, Lim F, Giner A, Mellman I, Zerial M and Murphy C (1998) Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. J. Cell Biol. 140: 1039-1053
Gournier H, Stenmark H, Rybin V, Lippé R and Zerial M (1998) Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J. 17: 1930-1940
Vitale G, Rybin V, Christoforidis S, Thornquist P-O, McCaffrey M, Stenmark H and Zerial M (1998) Two distinct Rab binding domains mediate the direct interaction between Rabaptin-5 and GTP-bound Rab4 and Rab5. EMBO J. 17: 1941-1951
Waite RL, Sentry JW, Stenmark H and Toh B-H (1998) Autoantibodies to a novel early endosomal antigen 1. Clin. Immunol. Immunopathol. 86: 81-87
Simonsen A, Lippé R, Christoforidis S, Gaullier J-M, Brech A, Callaghan JM, Toh B-H, Murphy C, Zerial M and Stenmark H (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394: 494-498
Gaullier J-M, Simonsen A, D’Arrigo A, Bremnes B, Aasland R and Stenmark H (1998) FYVE fingers bind PtdIns(3)P. Nature 394: 432-433
Kolpakova E, Wiedlocha A, Stenmark H, Klingenberg O, Falnes PØ and Olsnes S (1998). Cloning of an intracellular protein that binds specifically to mitogenic acidic fibroblast growth factor. Biochem. J. 336: 213-222
Stenmark H and Zerial M (1998). Lipofection. In "Cell Biology: A laboratory handbook", 2nd ed., vol.IV (Celis, J.E., ed.), Academic Press, pp. 141-144
Stenmark H and Zerial M (1998). Stock preparation of recombinant vaccinia virus. In "Cell Biology: A laboratory handbook ", 2nd ed., vol.I (Celis, J.E., ed.), Academic Press, pp. 540-543
Stenmark H and Zerial M (1998). Transient expression using the T7 RNA polymerase
recombinant vaccinia virus system. In "Cell Biology: A laboratory handbook",
2nd ed., vol.IV (Celis, J.E., ed.), Academic Press, pp. 201-203
1997
D'Arrigo A, Bucci C, Toh B-H and Stenmark H (1997) Microtubules are involved in bafilomycin A1 induced tubulation and Rab5 dependent vacuolation of early endosomes. Eur. J. Cell Biol. 72: 95-103
Horiuchi H, Lippé R, McBride H, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M and Zerial M. A complex of a novel Rab5 GDP/GTP exchange factor and Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90: 1149-1161
Olkkonen V and Stenmark H (1997). Role of Rab GTPases in membrane traffic.
Int. Rev. Cytol.176: 1-85
1996
Stenmark H, Aasland R, Toh B-H and D'Arrigo A (1996) Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J. Biol. Chem. 271: 24048-24054
Stenmark H, Vitale G, Ullrich O and Zerial M (1996) Rab5 GTPase, a control
switch in the early endocytic pathway. Zbl. Bakt. Suppl.28:
139-146
1995
Mu F-T, Callaghan JM, Steele-Mortimer O, Stenmark H, Parton RG, Campbell PL, McCluskey J, Yeo J-P, Tock EPC and Toh B-H (1995) EEA1, an early endosome-associated protein. EEA1 is a conserved a-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J. Biol. Chem. 270: 13503-13511
Singer-Krüger B, Stenmark H and Zerial M (1995) Yeast Ypt51p and mammalian Rab5: counterparts with similar function in the early endocytic pathway. J. Cell Sci.108: 3509-3521
Stenmark H, Vitale G, Ullrich O and Zerial M (1995) Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell 83: 423-432
Stenmark H, Bucci C and Zerial M (1995) Expression of Rab GTPases using recombinant vaccinia viruses. Meth. Enzymol . 257: 155-164
Stenmark H and Zerial M (1995) Role of the GTP/GDP switch for the function of rab5 in endocytosis. In "Biochemistry of cell membranes : A compendium of selected topics", Papa S and Tager JM (eds.) Birkhäuser Verlag, Basel, pp. 111-117
Stenmark H (1995) SNAREr og Rab-GTPaser: Veivisere i cellens indre. NBS-nytt 19,4, 7-11
Vitale G, Alexandrov K, Ullrich O, Horiuchi H, Giner A, Dobson C, Baykova
O, Gournier H, Stenmark H and Zerial M (1995). The GTP/GDP cycle of
Rab5 in the regulation of endocytic membrane traffic. Cold Spring Harbor
Symp. Quant. Biol. 60: 211-220
1994
Stenmark H, Valencia A, Martinez O, Ullrich O, Goud B and Zerial M (1994) Distinct structural elements of rab5 define its functional specificity. EMBO J. 13: 575-583
Singer-Krüger B, Stenmark H, Düsterhöft A, Philippsen P, Yoo J-S, Gallwitz D and Zerial M (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J. Cell Biol. 125: 283-298
Stenmark H, Parton RG, Steele-Mortimer O, Lütcke A, Gruenberg J and Zerial M (1994) Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J. 13: 1287-1296
de Hoop M, Huber L, Stenmark H, Williamson E, Zerial M, Parton RG and Dotti
CG (1994) The involvement of the small GTP-binding protein Rab5a in neuronal
endocytosis. Neuron 13: 11-22
1993
Ariansen S, Afanasiev BN, Moskaug JØ, Stenmark H, Madshus IH and Olsnes S (1993) Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region. Biochemistry 32: 83-90
Ullrich O, Stenmark H, Alexandrov K, Huber LA, Kaibuchi K, Sasaki T, Takai Y and Zerial M (1993) Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J. Biol. Chem. 268: 18143-18150
Zerial M and Stenmark H (1993) Rab GTPases in vesicular transport. Curr.
Opin. Cell Biol. 5: 613-620
1992
Stenmark H, Afanasiev BN, Ariansen S and Olsnes S (1992) Association between diphtheria toxin A- and B-fragment and their fusion proteins. Biochem. J. 281: 619-625
Stenmark H, Ariansen S, Afanasiev BN and Olsnes S (1992) Interactions of diphtheria toxin B-fragment with cells. Role of amino- and carboxyl-terminal regions. J. Biol. Chem. 267: 8957-8962
Madshus IH, Olsnes S and Stenmark H (1992) Membrane translocation of diphtheria toxin carrying passenger protein domains. Infect. Immun. 60: 3296-3302
Madshus IH and Stenmark H (1992) Entry of ADP-ribosylating toxins into cells. Curr. Top. Microbiol. Immunol. 175: 1-26
Olsnes S, Stenmark H, Moskaug JØ, Ariansen S, Madshus IH and Sandvig
K (1992) Internalization of diphtheria and related toxins. Zbl. Bakt.
Suppl. 23: 341-348
1991
Stenmark H, Olsnes S and Madshus IH (1991) Elimination of the disulphide bridge in fragment B of diphtheria toxin: effect on membrane insertion, channel formation, and ATP binding. Mol. Microbiol. 5: 595-606
Moskaug JØ, Stenmark H and Olsnes S (1991) Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions. J. Biol. Chem. 266: 2652-2659
Stenmark H, Moskaug JØ, Madshus IH, Sandvig K and Olsnes S (1991) Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol. J. Cell Biol. 113: 1025-1032
Madshus IH, Stenmark H, Sandvig K and Olsnes S (1991) Entry of diphtheria toxin-protein A chimeras into cells. J. Biol. Chem. 266: 17446-17453
Stenmark H (1991) GTPaser og intracellulær transport. NBS-nytt 15,4: 16-20
Stenmark H (1991) Interactions of diphtheria toxin and related proteins
with cells. Thesis for the Dr. Philos. degree. The Faculty of
Medicine, University of Oslo.
1990
Olsnes S, Stenmark H, Moskaug JØ, McGill S, Madshus IH and Sandvig K (1990) Protein toxins with intracellular targets. Microb. Pathogen. 8; 163-168
Olsnes S, Moskaug JØ, Stenmark H, McGill S and Sandvig K (1990) Translocation of diphtheria toxin across the plasma membrane. Zbl. Bakt. Suppl. 19: 127-135
Olsnes S, Stenmark H, Moskaug JØ, Madshus IH and Sandvig K (1990) Translocation of diphtheria toxin to the cytosol and formation of cation selective channels. J. Physiol. (Paris) 84: 191-196
Moskaug JØ, Stenmark H, Sandvig K and Olsnes S (1990). Requirements for diphtheria toxin A-fragment translocation into the cytosol. Zbl. Bakt. Suppl. 19, 191-192
Stenmark H, McGill S, Sandvig K, Collier RJ and Olsnes S (1990). Receptor
binding and membrane translocation of in vitro translated diphtheria toxin
mutants. Zbl. Bakt. Suppl. 19, 195-196
1989
McGill S, Stenmark H, Sandvig K and Olsnes S (1989) Membrane interactions of diphtheria toxin analyzed using in vitro translated mutants. EMBO J. 8: 2843-2848
Stenmark H, McGill S, Olsnes S and Sandvig K (1989) Permeabilization of the plasma membrane by deletion mutants of diphtheria toxin. EMBO J. 8: 2849-2853
Olsnes S, Stenmark H, McGill S, Hovig E, Collier RJ and Sandvig
K (1989) Formation of active diphtheria toxin in vitro based on ligated fragments
of cloned mutant genes. J. Biol. Chem. 264: 12749-12751
1988
Stenmark H, Olsnes S and Sandvig K (1988) Requirement of specific receptors for efficient membrane translocation of diphtheria toxin A-fragment across the plasma membrane. J. Biol. Chem. 263: 13449-13455
Olsnes S, Moskaug JØ, Stenmark H and Sandvig K (1988) Bacterial and plant protein toxins with intracellular targets - do they mimic entry of physiologically important proteins? In "Molecular mimicry in health and disease". Lernmark Å, Dyrberg T, Terenius L and Hökfeldt B (eds.) Elsevier, Amsterdam, pp. 197-210
Olsnes S, Moskaug JØ, Stenmark H and Sandvig K (1988) Diphtheria toxin entry: Protein translocation in the reverse direction. Trends Bioch. Sci. 13: 348-351
Stenmark H, Jacobsen J, Olsnes S and Sandvig K (1988). Preparation of monoclonal
antibodies against diphtheria toxin receptor. Zbl. Bakt.
Suppl. 17: 117-118
1987
Olsnes S, Moskaug JØ, Stenmark H, Tønnessen TI, Madshus IH
and Sandvig K (1987) Mechanisms involved in toxin entry into cells. In "Membrane-mediated
toxicity". Alan R. Liss Inc., pp 83-93
1986
Olsnes S, Stenmark H, Moskaug JØ and Sandvig K (1986) Binding and
uptake of diphtheria toxin by sensitive cells. In " Parasitic infections,
immunology, mycotic infections, general topics ". Marget W, Lang
W and Gabler-Sandberger E (eds.) MMV Verlag, Munich, pp. 229-232